Certified Pediatric Hematology Oncology Nurse (CPHON) Practice Exam 2025 - Free CPHON Practice Questions and Study Guide

In Warm Body Autoimmune Hemolytic Anemia (AIHA), the most commonly associated antibody is IgG. This condition is characterized by the body producing antibodies against its own red blood cells, and IgG plays a crucial role in this process. The specificity of IgG antibodies leads to their binding to the red blood cells, resulting in their destruction primarily in the spleen, where macrophages phagocytize the coated red cells.

Understanding the role of IgG in this condition is essential for effective diagnosis and management. Clinicians look for the presence of these antibodies to confirm a diagnosis of warm AIHA, as they are often detected in serological tests. The other types of antibodies mentioned do not typically play a significant role in this specific form of hemolytic anemia: IgM is more commonly associated with Cold AIHA, while IgA and IgE are related to different immune responses and conditions altogether. Therefore, recognizing the predominance of IgG in Warm Body AIHA helps in understanding the underlying mechanisms of the disease and supports appropriate treatment strategies.